[IIsi50MHz]

While evidence for temporary benefit from fluoride in toothpaste is somewhat positive, evidence for similar benefit from fluoridated water is mixed and has not been isolated from numerous confounding factors. Ingested fluoride at has some small potential for mildly adverse health effects. Whether common levels in municipal water supplier are a net benefit, harm, or neither remains debatable.

However, there is significant variation of thickness of tooth enamel, seemingly due to genetics.