[at_a_remove]

Dr. Hillman, I was right!

I had written him well over a decade ago, I want to say 2008. He has long since retired, but the gist of the hints in our correspondence was that this was something the FDA just didn't have a conceptual slot for, and that was creating a great deal of impedance. I believe he had gotten as far as Phase IB in testing.

[mmaunder]

Interesting use of 'impedance' as opposed to 'impediment'. I feel like you just birthed a neologism.

[at_a_remove]

I was thinking more in line of electrical impedance matching.