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by clord 1076 days ago
It’s worth noting that this was done in a sunny place, it would be better to test this in an a place with a darker winter, that being the reason so many people are deficient in D. What is the incidence of deficiency in the study population?
2 comments

It would likely be unethical to conduct a study to determine whether CVD risk is affected by vitamin D supplementation in those with vitamin D deficiency, because if you determine that study participants are vitamin D deficient then it is indicated to treat them regardless of impact on CVD risk. Thus the trial does not attempt to do such a thing, focusing only on a general sample, excluding anyone in whom vitamin D supplementation would be contraindicated.

Ultimately while it would be interesting to know if CVD risk is reduced with vitamin D supplementation in those who are vitamin D deficient, it is largely an academic question as those individuals should be taking vitamin D supplements anyway.