[haxiel]

Not a perfect solution to this scenario, but I have used multiple Firefox profiles in the past this way. The profiles are isolated at the file-system level, so extensions remain separate. So you could have a 'hardened' profile will all the blocking/cleaning extensions, and a 'trusted' profile with no extensions. Profile isolation also covers configuration, so you could even tweak those independently.

[ibejoeb]

I've experimented with that from time to time, but it hasn't stuck. The problem is when I click through. Container tabs handles that, but I would have to be extremely vigilant to prevent sites from loading outside of the hardened profile.