I recently learned Kyoto has rules about signage and specifically color saturation. Some of the rules seem too detailed, but the end result looks very nice. https://youtu.be/KuX3nu4jdo0
Slightly ironically given the gist of this discussion, the ad shown before that video was actually one I wanted to see and watched till the end (trailer for latest Indiana Jones movie).
I've applied a desaturation filter to a number of websites. The Register for example:
body {
/* A little less bloody red, eh? */
filter: saturate(33%);
}
(Via the Stylus CSS manager extension.)
I also browse extensively on an e-ink (monochrome) tablet, and find that the lack of high-saturation colour is very welcome. I suspect that even colour-based e-ink displays, given their muted pastel palette, might also be an improvement in general.
Edit: That's Stylus, not Stylish, as I'd initially written, Which has Gone To The Dark Side.