[IshKebab]

You can still interface with 5 volts using a level shifter. Which is exactly what this board uses so the 3.3V ESP32 can talk to the 5V Renesas chip.

[wmlavender]

I work for several beamlines at the Advanced Photon Source. There are probably far, far over 1,000,000 electronic signals at the whole APS facility that use 5 volt signaling. So almost any level shifting will be to embed 3.3 volt signals in a 5 volt world. It is simpler to buy equipment that has already done this.

[IshKebab]

Ok but this is an Arduino designed for hobbyists, not for scientists at the Advanced Photon Source.

[wmlavender]

No doubt. But lots of Arduinos have been used in scientific experiments because they are inexpensive and easy to work with. So the choices made in Arduino-like boards do affect us.