[ramraj07]

I don’t see how double blind is impossible here. Perhaps another drug that also gives you a high, on a base that has never taken any recreational drugs, could be viable?

[elevaet]

But that wouldnt be a great control since we'd be comparing the effects of psilocybin to that other drug instead of some kind of baseline.

[111111IIIIIII]

It would not be a control at all

[uxp100]

Wouldn’t it be an active control, which I believe is common in pharmaceutical research?

[abyssin]

Some studies use niacin for its sensation of flush.