[wl]

"Guys" tends to be neuter in the second person and masculine in the third person.

In any case, I think your example works better with a bisexual speaker. A straight guy would probably use more specific gendered language rather than a neuter construction. A bisexual person using "guys" to refer to the men and women (s)he has dated would be an example of a third person neuter usage—which I also think would be quite rare.