> You can explain one of the many reasons why gain of function research is necessary: anticipating next year’s version of the flu, designing drugs and vaccines such that resistance mutations reduce evolutionary fitness.
None of these require gain of function research.
> You can explain some of the safeguards in place: BSL 3/4 facilities, regulatory / institutional oversight, security services, etc.
All of these have a long history of failures [1,2]. And those are just the acknowledged, some have actually been covered up [3].
> None of these require gain of function research.
Please elaborate on this. How should I go about anticipating which mutations in which genes / protein will result in resistance to a candidate therapy / molecule / mechanism that I am considering advancing into phase 1 trials?
Please elaborate on this. How should I go about anticipating which mutations in which genes / protein will result in resistance to a candidate therapy / molecule / mechanism that I am considering advancing into phase 1 trials?