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by retrac 1102 days ago
> The claim from the company was that Oxycontin, which was a slow release form of oxycodone, was less addictive because of the slow release.

A similar claim is now made about Vyvanse, a pro-drug for amphetamine. Like a slow release formulation, but needs to be metabolized first. The slower onset, less sharp peak, makes it less euphoric for a similar effective dose, which is supposedly one of the mechanisms involved with the reward-feedback addiction cycle. Less likely to experience (intentionally or accidentally) the intense euphoria of a bit too much instant-release amphetamine on an empty stomach, and so less likely to seek out the experience again. It also frustrates injection, since it needs to be metabolized first so injecting it doesn't make it work any faster. I'm not sure the premise is wrong, and it is probably fairly similar with opioids. But slightly less abuse risk is certainly not the same as non-addictive.

1 comments

That’s interesting, I’ve been on vyvanse for five years now and never felt any of the telltale signs of dependency (which I am familiar with). I had to stop taking it for a month once and it just made me very drowsy for a week.