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by Vecr
1112 days ago
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Both the Pfizer-BioNTech and Moderna vaccines use a full length spike, look at the WHO definitions for elasomeran (Moderna) and tozinameran (Pfizer). For example, the Pfizer-BioNTech vaccine is described as "messenger RNA (mRNA) 5'[prime]-capped, encoding a full-length, codon-optimised pre-fusion stabilised[sic] conformation variant (K986P and V987P) of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2, GenBank: MN908947.3) spike (S) glycoprotein, flanked by 5'[prime] and 3'[prime] untranslated regions and a 3'[prime] poly(A) tail; contains N1-methylpseudouridine instead of uridine (all-U>[methylpseudouridine symbol]). immunological agent for active immunization (anti-SARS-CoV-2)". It's clearly full length, Pfizer abandoned their RBD-only candidate. |
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