Sure. For instance, there are times when you need to pack strings tightly together. Adding an extra byte or two before the start of the string would get in the way. You could work around it in many cases, but it makes the code uglier and harder to understand/maintain.
One of the things that makes C particularly suitable for certain sorts of tasks is that it's mostly WYSIWYG when it comes to the relationship between data structures and the actual memory layout. Having "hidden" things like a length value before the string steps on that.
if you wanted to pack strings together tightly, couldn't your string library have a separate "array" concept where all the sizes are stored separately?
I can read the data into a single string buffer, replace the commas with NULs, and set up strings pointing to the middle of the buffer;
Even better, the protocol might have NUL characters already in the code, expecting C strings to point to the correct start.