[tbenst]

Thanks! That is interesting and well reasoned.

If one wants to change neural computation via a global oscillator, it would seem that a flashing light, auditory tone, or tactile vibration might be a more potent alternative. These stimuli indisputably drive substantial brain wide activity, including many action potentials. I suppose I’m reluctantly team Firing Rate when it comes to mammals—there’s beautiful work on spike ordering in cold blooded animals for example but I’m less aware of computational work where precise spike time matters and not the relative time ie hebbiwn plasticity.

I’m also somewhat influenced by my first hand difficulty when doing in vitro patch clamp to induce sub threshold voltage changes on a neuron with a second probe even just 100um away. Color me skeptical, in part as it’s really hard to do a double-blinded control and the effect sizes seem small.