|
|
|
|
|
by napier
1120 days ago
|
|
Municipal water fluoridation is problematic for a range of reasons but as a toothpaste and mouthwash it has merit and it actually does demonstrate direct bacterial growth arrest effects in addition to indirect substrate permissiveness inhibition via mineralisation. “Fluoride acts to enhance membrane permeabilities to protons and compromises the functioning of F-ATPases in exporting protons, thereby inducing cytoplasmic acidification and acid inhibition of glycolytic enzymes.Basically, fluoride acts to reduce the acid tolerance of the bacteria. It is most effective at acid pH values. In the acidic conditions of cariogenic plaque, fluoride at levels as low as 0.1 mM can cause complete arrest of glycolysis by intact cells ofStreptococcus mutans.Overall, the anticaries actions of fluoride appear to be complex, involving effects both on bacteria and on mineral phases. The antibacterial actions of fluoride appear themselves to be complex but to be dominated by weak-acid effects.”
https://cdnsciencepub.com/doi/10.1139/m95-133#:~:text=Basica.... |
|