[cpncrunch]

>I'm not terribly surprised that ketamine may not produce strong antidepressant effects if the patient is not conscious.

That's incorrect, it actually produced larger antidepressant effects (50% response rate and 40% remission [1]) than when the patient is conscious (40% response rate and 30% remission according to a large meta-analysis [2]).

[1] https://www.medrxiv.org/content/10.1101/2023.04.28.23289210v... [2] https://pubmed.ncbi.nlm.nih.gov/35688035/

But that large response had nothing to do with ketamine, as the non-ketamine group had the same or higher response.

[bagacrap]

They only measured response for the next three days. Is it possible k has an effect for longer than three days while placebo only lasts three days or so?

[cpncrunch]

Unlikely. I see another comment says "The duration of the antidepressant effect is relatively short (days to weeks) and the antidepressant effect appears to diminish with repeated dosing."