[andybak]

Am I missing something blindingly obvious here? I would have assumed that the therapeutic effects of a strong mind-altering substance relies on being conscious to, you know, experience the effects.

Saying "It didn't work while the subject was asleep so therefore must be placebo" is just a bizarre position to take.

Imagine if a study stated "Cognitive Behavioural Therapy found to be ineffective on unconscious patients".

[cubefox]

The trip is very short, but the effect as a useful antidepressant has to last a lot longer. It's not clear why the trip itself would have anything but short term effects on depression.

[andybak]

Well, it's a hell of a lot clearer than a trip you slept through having a lasting effect.