[PragmaticPulp]

Ketamine depression treatment doesn’t have to induce a “trip” to elicit the effect, according to studies and the protocol.

It can produce some sensory distortions, but anyone who is going into a full “k hole” is almost certainly taking too much. It’s not a case of more is better.

[palmer_fox]

Is there a clear definition of a trip that these studies subscribe to? I would guess they attribute any change in perception to "tripping". K-hole is not the expected experience in most Ketamine-based treatments afaik.

[pas]

yes, but the phase 3 (efficacy) trial just barely crossed the threshold (if I remember correctly), mostly because the company wanted to use one stereoisomer because the other was not patentable (and this is the one that is less trippy)

https://slatestarcodex.com/2019/03/11/ketamine-now-by-prescr...