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I’ve used both, ketamine and SSRI (fluoxetine to be exact). Ketamine didn’t do anything for me, other than being a funny experience, but it certainly did nothing for my depression.

Fluoxetine also didn’t magically cure my depression, but it made me more risk taking. And I certainly got the anti-depressant effect from the rewards of taking such risks (asking someone out, applying for a new job, asking for extra ketchup on your fries).

It’s still the patients job to fight the disorder, and SSRI can certainly help.