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by namlem 1126 days ago
I believe propofol (common general anesthetic) is also known to have some antidepressant effect.
1 comments

Anything that puts you under and also inhibits REM sleep, can have effects against depression. REM sleep is important for memory consolidation, and consolidation of memory is linked to depression in that the reliving and reconsolidation of painful memories is thought to be involved in at least some types of depression.

This is why sleep deprivation can have an acute antidepressive effect, and also why cannabis can have a similar shorter effect in some cases. Usually when there's no tolerance.

I think it's quite possible indeed that something similar happened during this study.