[valec]

That's not what your comment said at all though.

>Neurotoxicity

unclear. on the onehand, unpublished studies in gorillas show no lesions. on the other, retroactive studies of heavy polydrug abusers show lesions. not super high-quality evidence either way. there's also rat studies showing lesions, but rats are unusually sensitive to neurotoxicity from dissociatives. they get similar lesions from nitrous oxide while humans get no such thing. honestly the potential bladder toxicity is more concerning imo.

>relapse rate

still much better success rates than SSRIs.

not saying ketamine is perfect --- would be better to have a purpose-built drug, and a lot of the clinics are kind of scummy and charge exorbitant prices. but this + non-psychedelic 5ht2a plastinogens are the most promising things to come out of depression research in the past 45 years.