[TeaBrain]

There may be better anti-aging drugs that have yet to be tested or discovered, but Rapamycin currently has the best data backing it up. It is the only drug which has consistently increased both median and maximum lifespan across organisms, for both males and females, across many trials. It has also been shown to increase lifespan when given to organisms after they have reached their middle age, which is not common.

The Interventions Testing Program (ITP) by the NIH, which has been testing substances for their effects on lifespan for over 15 years, is regarded as the gold standard for testing possible lifespan increasing substances. Rapamycin has outperformed every other substance they have tested, by a wide margin. There is only one other substance they have tested that has shown a median and maximum lifespan increase, for both females and males, that being acarbose. The greatest lifespan increase observed in any of the trials was seen with the combination of rapamycin and acarbose.

All of the substances that NIH ITP have tested with their results listed, as well as the interventions they are testing now: https://www.nia.nih.gov/research/dab/interventions-testing-p...

List of the substances they have tested with charts showing the relative increase in lifespan: https://phenome.jax.org/projects/ITP1