| Is it known what the mechanism is for metformin's effect on longevity? If it's due to its ability to reduce blood glucose levels, then berberine may be
another way to get a similar effect. Berberine stimulates glucose transport through a mechanism distinct from insulin https://www.sciencedirect.com/science/article/pii/S002604950... Efficacy of Berberine in Patients with Type 2 Diabetes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/ It also lowers cholesterol Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins https://www.nature.com/articles/nm1135 But pure berberine is not absorbed very well in the intestines, so you need to buy a good formation for it. Enhancement of sodium caprate on intestine absorption and antidiabetic action of berberine https://www.ncbi.nlm.nih.gov/pubmed/20237966/ Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability https://pubmed.ncbi.nlm.nih.gov/24607213/ The best thing might be to cook with barberries: https://thecaspianchef.com/2020/01/18/zereshk-polo-saffron-b... |