Yes, my ketamine doctor actually suggested this last year and prescribed me rapamycin as a booster with ketamine infusion sessions, citing this study referenced. He's done this for some patients who don't get infusions frequently, to try and stretch the positive effects longer.
It had a bit strange effects the first time I took the rapa, you dose it about 2 hours before ketamine infusion session. It actually attenuated the psychedelic effects of ketamine quite dramatically, which is interesting because the study predicted the rapamycin to strongly counteract certain effects of ketamine action, but the physical ketamine effects were still present for me. I did have the same positive mood boost starting later that day that I was used to with the infusions, I don't think the rapamycin hurt that effect and I was left with a good effect for some time afterwards.
What I was left wondering is, is the rapamycin actually amplifying the ketamine mood boost, or does it simply have a separate antidepressant effect that you can layer on by co-administering it? I took the rapamycin a couple times outside of session, and it did seem to give me an antidepressant effect for a few days as far as I can tell, of course not in a controlled study environment. But internally, I concluded that ketamine and rapamycin both have antidepressant effects that can both be used to positive effect, together or separately.
It had a bit strange effects the first time I took the rapa, you dose it about 2 hours before ketamine infusion session. It actually attenuated the psychedelic effects of ketamine quite dramatically, which is interesting because the study predicted the rapamycin to strongly counteract certain effects of ketamine action, but the physical ketamine effects were still present for me. I did have the same positive mood boost starting later that day that I was used to with the infusions, I don't think the rapamycin hurt that effect and I was left with a good effect for some time afterwards.
What I was left wondering is, is the rapamycin actually amplifying the ketamine mood boost, or does it simply have a separate antidepressant effect that you can layer on by co-administering it? I took the rapamycin a couple times outside of session, and it did seem to give me an antidepressant effect for a few days as far as I can tell, of course not in a controlled study environment. But internally, I concluded that ketamine and rapamycin both have antidepressant effects that can both be used to positive effect, together or separately.