[fowtowmowcow]

Does it threaten it or does it just threaten what's so far been established?

Presumably less demand for space will reduce cost of that space allowing for smaller, newer, experimental businesses to be able to buy into that space.

Commercial space can become less about being a place to work or to store a bunch of products to sell, to places where people meet and hangout, to train and collaborate, and to build synergies between businesses that benefit from sharing resources.