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by slibhb 1148 days ago
> Lore has it that the decisive insight for the double helix came when Watson was shown an X-ray image of DNA taken by Franklin — without her permission or knowledge. Known as Photograph 51, this image is treated as the philosopher’s stone of molecular biology, the key to the ‘secret of life’ (not to mention a Nobel prize). In this telling, Franklin, who died of ovarian cancer in 1958 at just 37, is portrayed as a brilliant scientist, but one who was ultimately unable to decipher what her own data were telling her about DNA. She supposedly sat on the image for months without realizing its significance, only for Watson to understand it at a glance.

I don't think this is what Watson wrote in The Double Helix. He wrote that Crick, with his background in math and physics, could understand the image produced by Franklin but that he -- Watson -- could not.

Watson does write that Franklin thought DNA wasn't helical. The linked article provides an interesting explanation for why she thought that (at least at one time). As far as I can tell, that backs up Watson's narrative rather than undermining it.

One interesting takeaway from The Double Helix was that Watson and Crick cracked the problem with guess-and-check model building (the article mentions this). Sure, they had some vague idea that DNA was a helix and that A-T, C-G relatinoship, but they basically played with tinker toys until they got something that looked good. Watson claims that they decided on a double helix because of his intuition that "in biology, important things occur in pairs".

1 comments

I believe that Franklin thought the DNA would be a triple helix like Pauling, not a double helix. And this is where Watson and Crick won out.
The article explains explains that, at one point, she didn't think DNA was helical.