[loonginthetooth]

You should review the psychological literature around sense of purpose. Basically every study ever conducted on humans has concluded that mental health is more or less impossible without a sense of purpose. The experts in this field say it's very likely that "helping them get over it" is either impossible or close enough that we'll never figure it out.

If, as you say, lack of purpose is inevitable and unfixable, many decades of research says humanity is doomed.