As much as I like hatchbacks and wagons, when a CR-V gets the same gas mileage as an Accord, I'm going to go with the CR-V. More stuff, more ground clearance.
The Honda HRV might -- it's now the "mid-sized" SUV. The CRV has now upgraded to the full-sized and is the basis for the Acura luxury models. The HRV is the size of the old CRVs.
I doubt the new/ current CRV would get a similar mileage, but could see the HRV doing so. Toyota offers similarly sized SUVs (e.g. the CH-R), and those come with hybrid options.
Higher ground clearance is usually associated with less fuel efficiency.