At times, I've had panic mode set in and _feel_ like I need to apply to every little job that looks remotely decent, but I don't know if that's _actually_ helping.
The more remotely decent the job is the more important it is to customize. I have hired people who have never worked in my niche before, but if all I see is irrelevant experience with no indication you want a new field you go in the pin. Convince me that despite not having the right experience you want a new field and you get a chance.
It's hard to say, it's all relative. I've had a couple first-round interviews for places that I care about, but those were also maybe because I had a referral at those places. In reality I'm not a super strong candidate because my entire resume is 1.5 year stints a decade in, and I haven't work anywhere noteworthy or something people recognize.