If you just look at the jihad, maybe it was comparable (As Frank eluded to it). But then there was Muad'dib's subsequent campaign against the known universe which killed billions, Leto II's golden path spanning 3,500 years of tyranny and the famine times before scattering. If I had to choose, it would be the blue pill, though chairdogs do contribute to a strong counter-argument.
I think I'd prefer the Matrix to the Harkonnens, but to each their own. I'm sure we can devise a Hell that has enough different arrangements for everyone's liking if we really put our mind to it. Or perhaps GPT-10 will solve that problem. ~