[joejohnson]

Fructose is metabolized primarily in the liver. Glucose is metabolized through many other (supposedly less deleterious) processes. HFCS is primarily fructose. Refined sugar is a mix of about 50-50 fructose-glucose. Thus, refined sugar is significantly different that HFCS.

[ScottBurson]

HFCS is 55% fructose; sucrose is 50% fructose. This doesn't strike me as "significantly different".