[genmud]

I may be confused as to what you mean by GUI in this context. If you are talking about a data exploration GUI... many, many scientists and physical science engineers use Jupyter/JupyterLab as a frontend for data exploration. This largely replaces the need for something like matlab.

If you are talking about practical implementation of those models, I have seen many non open source projects use those backends (things like pandas, sklearn, etc.) with things like django or flask as a frontend.