I sure hope not, GitHub is supposed to be matured infrastructure at this point, where most if not all changes going into production should be very well tested and nothing that multiple people haven't verified as being correct should end up being deployed and released.
Besides, Microsoft surely has 24/7 watch of their infrastructure, even on weekends, it's a huge company.
> Besides, Microsoft surely has 24/7 watch of their infrastructure, even on weekends
"watching" with a dedicated team vs "waking up everyone in engg because things are on fire" are two very different things.
Besides, size doesn't work that way. The larger the organization and the more complex the product is, the higher the chance some unexpected interaction will occur. There are processes and automation that can mitigate this, but one can never be completely certain.
What's your pager rotation like? I want to say you have follows-the-sun, and so your on-call shifts are 12-hours long and you swap with a team on the other side of the world from you so you can get said sleep, but I don't want to just assume that.
Less "on" hours then? Even Google has diurnal patterns when there's a lower amount of traffic simply due to the fact that humans are unevenly distributed across the Earth's surface. And Google does code freezes for the holidays where they don't deploy at all.