[gregjor]

Everything can't become meaningless because what we call meaning and purpose describe subjective interpretations, not inherent properties. My children mean a lot to me, but the meaning comes from me and my interactions with my children, not from a quality they possess (which is why my children don't mean anything to most people). It follows that nothing can "become meaningless," it can only cease to mean something in relation to you or me.

We have to find our own meaning and purpose in life, not look outside ourselves. I assume people reading my comment understand the distinction between higher purpose or meaning in the sense of the world at large, the universe, or the hereafter if you prefer, and what each of us finds personally meaningful or purposeful.

For myself, I found meaning and purpose from having children to raise. If I didn't have children I might find purpose in accumulating wealth, or finding a partner I enjoy spending time with, or traveling to see the world. Even hanging out with friends and laughing has some meaning, just not likely a cosmic meaning.

If a person needs to feel their life and (subjective) interpretation of their place and purpose in the world has importance and meaning outside of their subjective experience to stave off depression they should seek professional help. To imagine that what one does has significance, importance, and meaning beyond subjective experience seems like a symptom of delusion or narcissism.