[mrangle]

Blood concentrations rise because grapefruit slows liver processing. That's not the same as grapefruit increasing the risk of acetaminophen liver damage, which is the OD concern. I'm not saying it doesn't, but I've never read that warning and I've been taking it for fifteen years. You'd want to show the research that states that grapefruit increases acetaminophen toxicity.

They even sell extended release acetaminophen, which prolongs liver processing. Though, I'm not a fan because I think it is rougher on the liver. But health damaging risk is another issue.