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by yareally 1184 days ago
The Plague of Justinian (the first major instance of the disease) in the 6th Century wiped out at least 40% of the population of Constantinople--the largest and most advanced city in Europe at the time.

It's estimated it wiped out 25-60% of the population of Europe over the course of 2 centuries (15-100 million people).

https://en.wikipedia.org/wiki/Plague_of_Justinian