| Yes, I have. But yiou will really need your genetics to figure it out. There are many pathwyas that when slw or fast that can lead to anxiety. I have my genome and found that I carry a change in a gene called NOS1AP. This means I do not produce enough NOS1 (Neuronal Nitric Oxide Synthase, nNOS, CAPON) which leads to an influx of calcium through the NMDA receptor. https://pubmed.ncbi.nlm.nih.gov/25612209/ https://commons.wikimedia.org/wiki/File:CAPON_Binds_Nitric_O... So basically I have low NOS1 and typically higher amounts of glutamate and there for I am very excitable. Klonopin as needed helps in emergencies but I rely on a few dietary changes to limit bio-active compounds from inhibiting NOS1. These include limiting a large range of phenol's that inhibit NOS1 and avoiding air pollution (air purifier with activated carbon). P5P (B6) helps as well because I have issues truing glutmate to GABA via the GAD1 enzyme. I also eat lower protein and zero MSG like flavorings (Pea Protein Extract) Doing these things has lead me off of all my meds, which is huge. I also have latent CMV which at times effects me since it increases NMDA receptor function. CMV also gave me ankylosing spondylitis and lung nodules. https://bmcneurol.biomedcentral.com/articles/10.1186/1471-23... |
