[stephen_g]

That’s not incredibly surprising in older adults or people with chronic diseases - it probably just means that the intervention needs to happen much earlier.

Meshes with other studies I’ve read, like that people who were fitter in middle age have lower risk of alzheimers - so if you did an RCT of getting elderly people to do more exercise you’re not going to see much effect, since you’re not getting the years of cumulative protection from whatever it is that causes it and much of the damage is already done.