[zxienin]

Not all calories are equal. Calories from carb rich food are metabolized different than calories from “healthy“ fat rich food. Metabolism of former also raises insulin + glucose in blood stream, which influences obesity more than later.

[kuhewa]

The only way those differences really matter, as long as you are getting enough protein that you arent catabolizing muscle mass, is in what they do to how much you eat and perhaps exercise. Even if an insulin spike makes you crave junk food and not want to go for a walk, it's all still CICO to more than a first approximation.

[jjeaff]

Not to mention how different foods might affect different hormone levels and even the microbiome in your gut which seems to have a lot of affect on the brain as well as other systems.