[lightedman]

"UV units intended for installation in return or supply ducts are snake oil. A waste of electricity and money (the bulbs have a pretty finite lifespan.) The velocity of air in most ducts is such that anything flying by wouldn't be sterilized,"

If you just do the simple thing and point the lights in a self-facing ring in the duct, no, they will not work. The trick is to beam the light down the incoming pathway to drastically-increase the exposure time. Clean reflective surfaces in the ducting to even out the photon flux density will greatly help with this.