[acdha]

nginx is a much weaker proxy and doesn't allow as much customization as Varnish does. A coworker also ran into some basic HTTP compliance issues with nginx's cache and Vary headers - IIRC it simply ignores them outright. If you need more than very basic caching it's usually better to use Varnish because it's obsessively focused on doing that job well.

Depending on how you choose to implement it, this may also result in cleaner architecture if you have Varnish as a simple HTTP brick with little knowledge of the backend implementation, leaving all of the gory details to nginx.