[subroutine]

The first point being only a concern if you are a virus. If instead you are engineering say, an rna vaccine, you could package your transcript into lipofectamine instead of a coronavirus envelope ;) but point taken, there's always an upper limit.

[kevviiinn]

Also a concern when engineering viruses for research or other treatments such as the AAVs

[subroutine]

True. I should have said "if you are using a virus"