The Nevada section of US-50 is a particularly extreme case:
> In the stretch of highway between Fallon and Delta, Utah, a span of 409 miles (658 km), there are three small towns: Austin, Eureka, and Ely. This span is roughly the same distance as Boston, Massachusetts, to Baltimore, Maryland, or Paris, France, to Zürich, Switzerland.
Eyre Highway runs east from Norseman in Western Australia for 1,200 kilometres (750 mi) across the Nullarbor Plain to Ceduna, South Australia.
It then crosses the top of the Eyre Peninsula as it continues eastwards for 470 kilometres (290 mi), before reaching Port Augusta.
My wife and I drove that a few years ago on our NY-to-SF trip, and it was a truly memorable experience. And somewhere out in the desert you'd see a tiny wooden house left by a settler; we knew there was another town a few tens of miles further on and that we could be rescued if we broke down, but those early settlers... I can't get my head around that.
> In the stretch of highway between Fallon and Delta, Utah, a span of 409 miles (658 km), there are three small towns: Austin, Eureka, and Ely. This span is roughly the same distance as Boston, Massachusetts, to Baltimore, Maryland, or Paris, France, to Zürich, Switzerland.
Also known as the "Loneliest Road in America".
[0]: https://en.wikipedia.org/wiki/U.S._Route_50_in_Nevada