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by skazazes 1226 days ago
Intel has the NUC Extremes which offer a full x16 slot in a fairly small footprint. The Core of the computer itself looks like a small GPU, and it plugs into a daughter board that acts as a coupler for its two x16 slots.

I think most people throw GPU's in them but I don't see a reason why you couldn't just fit it with a nice NIC