[KMag]

Did you find a very skewed sex ratio in your embryos?

My dad has a sister, but has only two sons. My brother has 3 sons and one daughter, all natural pregnancies. My wife and I have 1 son via IVF, and the other 4 embryos we had checked for chromosomal abnormalities happened to all be male.

I am aware that some IVF processes can inadvertently introduce a sex bias by exacerbating the tiny speed advantage the lighter Y chromosome gives sperm.

I'm curious (and will never know) how much of the skewed sex ratio of my embryos is due to randomness, how much is due to IVF processes, and how much might be due to some familial abnormality.

[giberson]

We did. The majority were female embryos. I mentioned report cards, we had 5 embryo's with grade A, 1 of which was male. We had a similar prevalence for female with lower grades as well, though there were 2 or 3 males each in the lower grades.

[whythre]

There are some harmful genetic mutations that associate with particular sex chromosomes. I wonder if ease of detection in some varieties of abnormality may play an inadvertent role too.