You should start with his explanation of ruliad for a full understanding. But the ELI5 idea is that humans have limited mental capacity while reality is trying everything possible. So a lot of physical laws result from that interaction. In this article he does an informal explanation of how a future, formal derivation of the second law of thermodynamics could be done and what problems need to be solved in order to do that (specifically better definition of observers).
I spent ten minutes reading this and lost interest. Everything he explains in the beginning of this article is obvious or common sense (common sense for anyone who has a physics degree, that is) and I am not sure where the "new" things he discovered begin. There is a reason that academic papers are required to have an abstract, an introduction section and a conclusion section. Unfortunately Mr Wolfram seems to think that his endless rambling can convey scientific discovery better.