[jcranmer]

Ostensibly, only one prefix from each group can matter. Although I did notice that XACQUIRE and LOCK are both group 1 prefixes, which makes that statement kind of a lie (but it's an intentional design to make XACQUIRE do nothing on processors that don't support it).

In any case, there's only a finite number of prefixes you can meaningfully stick onto an instruction, and repeating the same prefix will do absolutely nothing.