[ridruejo]

This one is designed to run on the server side and interface with the OS via WASI, so it can read/write files etc

[dom96]

Pyodide can do so too, though through an emscripten interface. I managed to get it running on Cloudflare Workers as a POC[0] (though I should add a disclaimer that I work at Cloudflare)

0 - https://github.com/dom96/pycloud