[monknomo]

It's an interesting problem - I was reading about bipolar, which also (probably) has the issue of too open a blood-brain barrier. There is a theory that repairing the blood-brain barrier would help, but as drugs repair the barrier, it's harder to get drugs into the brain from the blood, which means the doses need to be higher, which means the side effects are worse.

I could imagine a treatment protocol of opening the blood-brain barrier and then administering a low dose of a drug, or something along those lines