Yamanaka factors seem to be a reinit mechanism, however that's not enough.
Cell differentiation seems to be similar to Conway's Game of Life where cells differentiate based on neighboring cells. Significant ordered complexity can emerge from simple rules. Now if you go and reset random cells, often it is either a no-op or they pick up the correct state from neighbors, but if you keep doing it, you eventually reset an important cell and break the functionality.
Cell differentiation seems to be similar to Conway's Game of Life where cells differentiate based on neighboring cells. Significant ordered complexity can emerge from simple rules. Now if you go and reset random cells, often it is either a no-op or they pick up the correct state from neighbors, but if you keep doing it, you eventually reset an important cell and break the functionality.
In biology, it likely looks a little more like this: https://www.youtube.com/watch?v=7-97RhAZhXI