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by generalizations
1252 days ago
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Interesting publication by Sinclair back in 2021: Reprogramming to recover youthful epigenetic information and restore vision > Using the eye as a model CNS tissue, here we show that ectopic expression of Oct4 (also known as Pou5f1), Sox2 and Klf4 genes (OSK) in mouse retinal ganglion cells restores youthful DNA methylation patterns and transcriptomes, promotes axon regeneration after injury, and reverses vision loss in a mouse model of glaucoma and in aged mice. [0] https://www.nature.com/articles/s41586-020-2975-4 |
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